We found 2 RCTs that evaluated topical steroid/antiseptic combinations in the treatment of clinically infected atopic eczema18,19 (Table 17.6). The first study, by Meenan, showed no difference in efficacy between Triadcortyl cream and Locoid C.18 In the second study by Zienicke,19 a topical steroid/antiseptic was compared with topical steroid alone; 0-25% prednicarbate/didecyldimethylammoniumchloride cream and 0-25% prednicarbate cream were both effective at reducing clinical scores and bacterial counts, with no significant difference between them.19

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