One single-blind randomised study136 compared terbinafine pulse with sequential treatment in which two itraconazole pulses were followed by terbinafine pulse (see Table 33.4). The mycological cure rate in the terbinafine group was 49%, and therapy was effective (mycological cure plus at least 5 mm of new nail growth) in 46% of patients, with 32% of patients completely cured (n = 90).
In the two open randomised comparative studies,169,170 intermittent terbinafine therapy was associated with complete cure rates of 50% (n = 20)169 and 74% (n = 23).170 Furthermore, in the study by Tosti et al.169 the mycological cure rate was 80% (n = 20).
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