In the first of two RCTs, 29 patients received metronidazole, 400 mg/day for 6 weeks. The benefit was significantly superior to placebo.9 In the second trial, 40 patients received 400 mg/day for 12 weeks. The improvement was similar to that obtained with oxytetracycline.10 An uncontrolled trial treated 59 patients with 500 mg/day for no more than 6 months, obtaining 90% success.11 Some trials published in German were not available to me.12

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