We found one large RCT in which 109 patients were randomised to receive either 1% metronidazole cream (applied twice daily) plus placebo tablets or tetracycline tablets (250 mg twice daily) and a placebo cream.3 Patients who had been treated with antibiotics or other medications in the 4 weeks before initiation of the trial were not included. ln the group of patients given metronidazole the median number of papules was reduced to 33% of the original number after 4 weeks, and to 8% after 8 weeks. The median number of papules in patients given tetracycline reduced to 4% after 4 weeks, and to 0 at 8 weeks. Tetracycline was significantly more effective in reducing the number of papules both after 4 weeks and 8 weeks of treatment (P<0-01). No significant differences were noted between the two groups for erythema, and patient and physician assessments, which were the other categories evaluated.
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Rosacea and Eczema are two skin conditions that are fairly commonly found throughout the world. Each of them is characterized by different features, and can be both discomfiting as well as result in undesirable appearance features. In a nutshell, theyre problems that many would want to deal with.