Efficacy

We found no systematic review.

Four RCTs have compared pretreatment with oral antihistamines with placebo in VIT.

• In 140 patients cetirizine significantly reduced local adverse reactions but not systemic adverse reactions.109

• In 54 patients fexofenadine significantly reduced local adverse reactions but not systemic adverse reactions.110

• In one RCT (n = 52) terfenadine significantly reduced local adverse reactions but not systemic reactions.111

• In the second RCT (n = 121) terfenadine significantly reduced both systemic adverse reactions and local adverse reactions during the first week.112

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