Efficacy

Rosacea Free Forever

Rosacea Free Forever Cure By Laura Taylor

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The AHRQ systematic review14 examined seven placebo-controlled RCTs in patients with mild-to-severe acne42 53-58 (see Web Table 13.2). Changes in both NIL and IL were consistently significantly superior in the active group. Two RCTs reported mean reductions in lesion counts with 5% benzoyl peroxide: 52% and 60% for IL and 30% and 52% for NIL.42 55 The reductions in the vehicle comparator arms were less than 10% in each case. Four RCTs compared different dosages of benzoyl peroxide48,53,59 and no evidence was located to support a dose-response effect (Table 13.2).

Three RCTs compared topical tretinoin with 5% benzoyl peroxide.49,50,60 Tretinoin was shown to be more effective against NIL up to 12 weeks, but benzoyl peroxide had a greater impact on IL.

Author Comparators Number Severity Duration Blinding Outcomes Comments

Mills etal. 1986(2)55

1. 2.

BP 2-5% BP 5%

53

1/2

8

P, A

Equivalent efficacy and burning, peeling and erythemal

IL: 56% 1/58% reduction

2 LTF; not clear If randomised

Mills etal. 1986(3)55

1. 2.

BP 10% BP 2-5%

50

1/2

8

P, A

Equivalent efficacy but 10% more burning, erythema and peeling IL: 45% 1/47% reduction

No LTF; not clear If randomised

Yong 1979-

1. 2.

BP 2-5% BP 5 %

200

1/2/3

4-18

0

>50% reduction In lesion counts 64/96 1/74/98 (no SSD); erythema 45 1/50; desquamation 22 1/28; Itching/burning 16 v 10; no SSD overall

6 LTF, arms not comparable; Asian population; twice-daily application; Variable duration of treatment

Tretinoin 0-05%/ BP 10%

250

1/2/3

10

0

Overall change greater In 5% combination group; rate of local Intolerance 20% both groups but greater In 10% group; >50% reduction In NIL: 34/47 1/37/45 1/ 33/47 1/ 45/50 1/ 44/50 >50% reduction In IL: 27/36 v 34/42 1/28/41 1/34/44 1/39/49; no SSD between BP concentrations

11 LTF; not ITT; 47 patients needed alterations due to adverse reactions

BP 5%/0-5 g OT BP 5%/1 g OT BP 5%/1 -5 g OT

82

1/2/3

16

A

Patient adequate response: 2/23 1/6/24 1/8/19 1/12/17;

10 BP patients local Intolerance; IL: 56 1/70 1/75% 1/78% reduction

Assume randomised but not stated; previous failure to treatment; 10 LTF; not ITT

Fryand and Jakobsen 1986202

1. 2.

BP 5% (alcohol) BP 5% (water)

48

-

8

P, A

No difference In clinical effect but less Irritation In water-based preparation

Abstract only

Number, number of patients enrolled; severity (1 = mild; 2 = moderate; 3 = severe); duration (weeks); blinding (0 = open; A = assessor; P = patient); LTF, lost to follow up; ITT, Intentlon-to-treat; (N)IL, (non)-lnflamed lesions; SSD, statistically significant difference

Number, number of patients enrolled; severity (1 = mild; 2 = moderate; 3 = severe); duration (weeks); blinding (0 = open; A = assessor; P = patient); LTF, lost to follow up; ITT, Intentlon-to-treat; (N)IL, (non)-lnflamed lesions; SSD, statistically significant difference

Compared with topical 0-05% isotretinoin, 5% benzoyl peroxide had a greater effect on IL at 8 weeks but not 12 weeks and a similar effect on NIL at all time points in 77 patients with mild-to-moderate acne42; 5% benzoyl peroxide has similar efficacy to 20% azelaic acid in mild acne.61

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How To Deal With Rosacea and Eczema

How To Deal With Rosacea and Eczema

Rosacea and Eczema are two skin conditions that are fairly commonly found throughout the world. Each of them is characterized by different features, and can be both discomfiting as well as result in undesirable appearance features. In a nutshell, theyre problems that many would want to deal with.

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