We found no systematic review.
Hydrocortisone butyrate versus 1% hydrocortisone alcohol cream
One double-blind, split-face randomised trial with 28 patients (8 patients with perioral dermatitis, 18 patients with rosacea, and 2 patients with atopic dermatitis), randomly treated one side of their face with hydrocortisone alcohol 1% cream and the other side with 0-1% hydrocortisone butyrate.16 Only patients with severe disease were selected. Participants were instructed to apply the creams twice daily to the appropriate side of the face. Six of 8 patients with perioral dermatitis were also given oxytetracycline, 250 mg twice daily. Patients were re-examined weekly by the same physician until more improvement was noted on one side of the face compared with the opposite side. If no difference was detected, treatment continued for up to 3 months. In addition, patients were re-examined 1 week after treatment was withdrawn to determine whether any rebound occurred. Two patients with perioral dermatitis achieved better results with hydrocortisone alcohol 1% cream (mean duration of therapy 3-5 weeks; range 3-4 weeks), four patients improved with hydrocortisone butyrate (mean duration 3-5 weeks; range 2-5 weeks) and two patients found the two treatments to be equally effective.
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Rosacea and Eczema are two skin conditions that are fairly commonly found throughout the world. Each of them is characterized by different features, and can be both discomfiting as well as result in undesirable appearance features. In a nutshell, theyre problems that many would want to deal with.