Efficacy

We found two trials comparing griseofulvin with placebo in cutaneous LP.19,20 The first included two groups of 17 patients who received either placebo or griseofulvin, 500 mg/day, for 4-6 weeks.19 "Complete regression" was observed in 71% of griseofulvin-treated patients compared with 30% of placebo-treated patients. The definition of a cure was based only on flattening of lesions and reduction of itching. In the second study, 44 patients with cutaneous LP were treated with griseofulvin, 500 mg/day, or placebo for 8 weeks.20 Griseofulvin resulted in "complete improvement" in 82% of patients whereas "partial remission" occurred in 23% of placebo-treated patients.

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