Efficacy

Versus placebo

Four RCTs involving 90 people compared either topical or systemic PUVA with placebo. Fifteen of 36 (42%) receiving oral PUVA cleared, compared with 0 of 36 (0%) receiving placebo: success rate difference 0-42 (CI 0-25 to 0-58). One of 54 (2%) receiving topical PUVA cleared, compared with none of 54 receiving placebo: success rate difference 0-02 (CI -0-04 to 0-08).

Topical PUVA versus systemic PUVA

In the one RCT identified (n = 64), 4 of 51 (8%) cleared with topical PUVA compared with none of 13 who received systemic PUVA: success rate difference 0-08 (CI -0-05 to 0-21).

Versus retinoids

See above.

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