Efficacy

No systematic reviews or RCTs were identified. Dose-response studies have clearly established that localised superficial radiotherapy is an effective palliative therapy for individual lesions in mycosis fungoides.70 A retrospective study of palliative superficial radiotherapy used to treat 191 lesions from 20 patients with mycosis fungoides showed CRs of 95% for plaques and small (<3 cm) tumours and a CR of 93% for large tumours (>3 cm), irrespective of dose. However in-field recurrences within 1-2 years were more common for those lesions treated with lower doses (42% for <1000 cGy, 32% for 1000-2000 cGy, 21% for 2000-3000 cGy and 0% for >3000 cGy).

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