We found one systematic review.5 Versus placebo

We found one randomised controlled trial (RCT) comparing hexachlorophene with placebo.6 Scrubbing with hexachlorophene added no notable benefit to placebo treatment.

Versus topical antibiotic treatment

One multicentre RCT compared hydrogen peroxide cream with fusidic acid cream/gel.7 There was no significant difference in treatment effect, but there was a tendency towards a better effect of fusidic acid cream/gel. There was no significant difference between hexachlorophene and bacitracin ointment in a small and ancient study.6

Versus oral antibiotic treatment

Hexachlorophene scrubbing was much less effective than oral treatment with penicillin.6

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