Efficacy

We found no systematic review or RCTs. We found two case reports which studied 17 children between the ages of 9 months and

9 years with perioral dermatitis.4,5 Eleven of the 17 children were treated with 0-75% metronidazole gel either once or twice daily. The remaining patients were given metronidazole gel in combination with topical corticosteroids or erythromycin (topical or oral). All patients improved significantly within 8 weeks of therapy. Fourteen patients who were followed up remained lesion-free for up to 16 months.4

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