Efficacy

Topical class 3 corticosteroids have been shown to be effective in localised vitiligo, with a pooled OR of 14-3 (CI 2-4-83-7); pooled ORs showed non-significant differences between topical class 4 or intralesional corticosteroids and their respective placebos.10 Treatment duration in the trials varied from 5 to 8 months, and strongly depended on the response: when no response occurred after 2-3 months, therapy was stopped.

The efficacy of oral corticosteroids in generalised vitiligo was low, with fewer than 20% of patients achieving >75% repigmentation in 4-24 months.10

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