Efficacy

In one RCT of Grenz ray therapy, 13 of 17 sides receiving Grenz ray showed greater improvement than the contralateral side; by comparison an advantage was seen in only one of 17 sides receiving placebo. The author commented that the degree of improvement was modest. One of two RCTs comparing colchicine with placebo claimed benefit from the former but at the expense of troublesome side-effects. There is no good evidence from RCTs to support the use of tar or anthralin. There are no RCTs of methotrexate therapy for chronic palmoplantar pustular psoriasis. In an uncontrolled prospective study eight of 25 people given methotrexate, 25 mg weekly for 2 months, achieved a good or excellent response. The response rate appeared greater in those with evidence of psoriasis elsewhere (six of 12) than in those without (two of 13).110

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Natural Treatments For Psoriasis

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