We found one RCT and one open study. The open study was initially conducted as a doubleblind trial with crossover, and compared fluocinonide in an adhesive base with placebo in 11 patients.21 A partial response was observed in five patients and a complete response in six patients in the fluocinonide group, compared with one partial response in the placebo group. Subsequently, 56 other patients were treated openly, 29 obtained a complete response after 2 weeks of therapy. The exact number of relapses is impossible to calculate because various oral diseases were mixed in the follow-up study. In the second RCT,22 fluocinonide in an adhesive base, applied 6 times per day for 9 weeks, was compared with its vehicle in 40 patients with oral LP. This study included 12 patients with erosive LP, 13 with reticular LP, and 15 with a combination. Thirteen of the 20 treated patients obtained complete remission or had a good response, compared with four good responses in the placebo group.
We found one open study and one RCT. The RCT23 compared betamethasone valerate aerosol, four sprays per day for 2 months, with placebo in 23 patients with oral LP, 18 of whom had erosive lesions. After 2 months of therapy, eight of 11 patients had a "good or moderate" response (6 of them having erosive LP) compared with 2 moderate responses in the placebo group.
The open study24 was conducted in 30 patients with oral LP, treated topically four times daily. Twenty patients showed significant improvement after 1-12 months of treatment.
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