One systematic review (search date 1999, 6 RCTs, 258 people)59 included all the RCTs identified by the present search.
In the two RCTs comparing the standard compound fumaric acid ester therapy (maximum dose 1290 mg ester mixture daily) with placebo (n = 123), 34 of 61 (56%) people treated for up to 16 weeks achieved at least a 70% reduction in PASI score whereas only 5 of 62 (8%) receiving placebo showed similar improvement (rate difference 0-47, CI 0-33-0-61).9697 Two RCTs comparing fumaric esters monotherapy with placebo showed benefit from dimethylfumarate (n = 42) but not monoethylfumarate (n = 38).98
Fumaric acid ester regimens compared
In one RCT (n = 45) no difference in efficacy between Fumaderm and dimethylfumarate monotherapy could be demonstrated.99
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Do You Suffer From the Itching and Scaling of Psoriasis? Or the Chronic Agony of Psoriatic Arthritis? If so you are not ALONE! A whopping three percent of the world’s populations suffer from either condition! An incredible 56 million working hours are lost every year by psoriasis sufferers according to the National Psoriasis Foundation.