Efficacy

One systematic review was found,26 based on case series only (a total of 39 series, reporting on five different techniques). The highest success rates occurred with split-thickness grafting and suction blister epidermal grafting, with 87% of patients achieving >75% repigmentation (sample-size weighted averages, CI 82-91 and 83-90, respectively). With minigrafting, 68%

(CI 62-64) of the patients were successfully grafted. A trial comparing minigrafting and suction blister epidermal grafting27 confirmed the results of the review, although the outcome measure was the proportion of patches instead of the proportion of patients. In a placebo-controlled trial on 18 patients, the addition of a melanotropin analogue applied topically on minigrafted patches did not improve the success of the minigrafting.28

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