Oral photochemotherapy

We found four open studies and one RCT.3 The controlled study of oral PUVA therapy was conducted on 18 patients with erosive or ulcerative oral LP, after ingestion of psoralen, 0-6 mg/kg, and randomised unilateral irradiation.38 The endpoint was comparison of the treated and non-treated sides. After 12 sessions (total dose 16.5 J/cm2), the treated side showed a marked or slight improvement in 13 patients and the control side improved in six patients.

Extracorporeal photochemotherapy

We found a small series of seven patients with severe resistant erosive oral LP treated with extracorporeal photochemotherapy.39 Complete remission was obtained in all patients.

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