In the first RCT, 20 patients were treated for one month with a 10% sulphur cream plus placebo tablets and compared with 20 patients treated with lymecycline, 150 mg/day, plus placebo cream. Ninety-two per cent of lesions cleared with both treatments.49 In the second study, a total of 94 patients were treated with a combination of 10% sodium sulfacetamide and 5% sulphur in a lotion for 8 weeks. Inflammatory lesions decreased by 78% versus 36% in the vehicle group.50

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