One systematic review of calcipotriol (search date 1999, 37 RCTs, 6038 people)22 has been published. The authors concluded that calcipotriol is an effective treatment for mild-to-moderate chronic plaque psoriasis, more so than calcitriol, tacalcitol, coal tar or short contact anthralin and that, amongst topical therapies with which it has been compared, only potent topical corticosteroids seem to have comparable efficacy at 8 weeks. Although calcipotriol causes more skin irritation than topical corticosteroids, this has to be balanced against the potential long-term effects of corticosteroids. Skin irritation rarely led to withdrawal of calcipotriol treatment. The combination of calcipotriol cream applied in the morning with a moderately potent to potent topical corticosteroid at night has been shown to be at least as effective as twice-daily calcipotriol cream but to cause significantly less irritation.23 More recently, a compound ointment containing calcipotriol, 50 microgram/g and betamethasone dipropionate, 0-5 mg/g, has been evaluated in a RCT involving 1106 people with chronic psoriasis. Participants were randomised to receive 4 weeks' twice-daily treatment with the combination ointment or with marketed formulations of one or other of its two active constituents, followed by twice-daily calcipotriol, 50 microgram/g ointment for a further 4 weeks.24 The mean percentage decrease in psoriasis severity score at 4 weeks was 74-4% in the combination group (n = 372), 55-3% in the calcipotriol group (n = 369) and 61-3% in the betamethasone group (n = 365). These differences were highly significant. At the end of 8 weeks, however, the severity scores did not differ.
Was this article helpful?
Do You Suffer From the Itching and Scaling of Psoriasis? Or the Chronic Agony of Psoriatic Arthritis? If so you are not ALONE! A whopping three percent of the world’s populations suffer from either condition! An incredible 56 million working hours are lost every year by psoriasis sufferers according to the National Psoriasis Foundation.