Efficacy

We found two randomised, double-blind, placebo-controlled trials and one open trial with 8% lithium succinate ointment.26-28 One crossover trial in nine centres (200 patients) and a parallel-group study in two centres (27 patients) showed that symptom score improved significantly in the lithium group (P<0-0001).26 The other double-blind trial, conducted in twelve patients with AIDS-associated seborrhoeic dermatitis, showed a rapid (2-5 days) and significant (P<0-01) clinical improvement in patients treated with lithium succinate.27

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