Efficacy

Overall, the average response rate for the six regimens was 91%, as defined by absence of any tumour on the basis of histological analysis of excised specimen A 100% complete response rate was observed in patients who received 5 ml 5-FU/epinephrine gel twice weekly for 4 weeks -a 92% response rate for superficial lesions and a 91% response rate for nodular lesions.

All regimens appeared to work well and there were no statistically significant differences between them. The various treatment regimens with higher doses and/or treatment frequency resulted in higher complete response rates than obtained in an earlier pilot study.42 Cosmetic appearance of lesion site prior to excision at 3 months ranged from good to excellent.

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