Efficacy

No RCTs were found. Broadband UVB (290-320 nm) phototherapy with maintenance therapy produced CR in 83% of 35 patients with early-stage disease (IA/IB) with a median response time of 5 months and median response duration of 22 months.24

Narrowband UVB (TL-01; 311-313 nm) also produces CR in 75% of patients (6/8 cases with early patch-stage (IA) disease) with a mean duration of response of 20 months.25

High-dose UVA1 phototherapy (340-400 nm; 100 J/cm2 on a 5 day per week basis) has been used in 13 patients (8 stage IB, four stage IIB and one stage III) until maximal response. Eleven of the 13 patients showed a CR, defined as a complete resolution of cutaneous lesions (mean number of sessions 22; cumulative dose 2149 J/cm2) and seven patients remained in CR after a mean follow up of 7-2 months.26

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