Fluorouracil 5FU

The primary mechanism of action of 5-FU is thought to be inhibition of DNA synthesis

Table 26.6 Randomised controlled trials evaluating 5-fluorouracil (5-FU) in the treatment of basal cell carcinoma

Study Method Participants Interventions Outcomes Notes

Table 26.6 Randomised controlled trials evaluating 5-fluorouracil (5-FU) in the treatment of basal cell carcinoma

Study Method Participants Interventions Outcomes Notes

Ramgosa et al.

Single centre

13 patients, 17 BP

T1: 5% 5-FU in PC

FU: every 4 weeks for

Ex: systemic disease,

200040 (USA)

Method of

non-S BCCs > 0-7 cm

vehicle T2: 5% 5-FU

16 weeks

women of

randomisation

greatest diameter

in petrolatum base

Final visit was biopsy

childbearing age,

not known

Applied am and pm

of site

facial BCCs.

ITT

for 4 consecutive

weeks

Miller et al.

Multicentre,

97 males, 25 females

6 treatment regimens

FU examinations of

Ex: high risk sites.

199741

randomised,

Single BP BCC

with 5-FU/epi gel: T1:

patients at 1, 4, 8,

Lesions with deep

(USA)

open-label

Mean age 61 years

1.0 ml once weekly

12 weeks after last

tissue involvement,

Method of

Histological type:

for 6 weeks; T2: 0-5

injection

basal cell naevus

randomisation

38 S, 85 N

ml once weekly for

At each visit patient

syndrome,

not known

Location: 9 head,

6 weeks; T3: 1-0 ml

and investigator gave

hypersensitivities or

PP

9 neck, 38 upper

twice weekly for

subjective evaluation

allergies to 5-FU,

extremities, 11 lower

3 weeks; T4: 0-5ml

of cosmetic

sulfites, epinephrine,

extremities, 55 trunk

twice weekly for

appearance of lesion

bovine collagen,

Lesion area median

3 weeks. T5: 0-5 ml

history of autoimmune

80 mm2

twice weekly for

disease, pregnancy.

4 weeks, T6: 0-5 ml

Six patients were lost

three times weekly

to follow up

for 2 weeks

See Table 26.1 for abbreviations.

See Table 26.1 for abbreviations.

by competitive inhibition of thymidylate synthetase.39

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