For some 20 years a mixture of dimethyl and monoethyl esters of fumaric acid has been used widely in Northern Europe, particularly in German-speaking countries, as a systemic treatment for severe psoriasis. The evidence for the efficacy of oral fumaric acid therapy has been considered in a systematic review59 which concluded that it is an effective systemic treatment for psoriasis. Of the constituents of the standard compound fumaric acid ester therapy in use in Northern Europe (Fumaderm), dimethylfumarate appears to be the principal active component although only the compound mixture has thus far been licensed for clinical use. Formal comparisons with topical or with other systemic therapies have not been performed. The incidence of symptomatic side-effects is high.
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Do You Suffer From the Itching and Scaling of Psoriasis? Or the Chronic Agony of Psoriatic Arthritis? If so you are not ALONE! A whopping three percent of the world’s populations suffer from either condition! An incredible 56 million working hours are lost every year by psoriasis sufferers according to the National Psoriasis Foundation.