Complications of cryotherapy include pain, poor healing and infection, requiring antibiotics.42 Patients were 10-4 times more likely to report pain with cryotherapy (P<0-001), and were 5-5 times more likely to report pain on the lower leg compared with other body sites, irrespective of treatment method (P<0-016).42 Poor healing occurred in 2% of patients who received cryotherapy in this retrospective comparison study.43 Poor healing was defined as a residual ulcer requiring salvage surgery, that ceased to show signs of continuing reduction in diameter, or considered by the dermatologist to be progressing poorly over at least 3 months. Biopsy of these poor-healing lesions revealed residual tumour. The authors speculate that failure to heal may suggest residual BD, and may be an indication for surgical excision.

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