Dinitrochlorobenzene is mutagenic on the Ames test.18 A moderately severe allergic contact dermatitis is necessary for success of the therapy,19 which if severe may necessitate temporary suspension of treatment. Tender regional lymphadenopathy is common, but usually mild and self-limiting. Generalised dermatitis is uncommon but may necessitate permanent cessation. Contact urticaria, vitiligo and erythema multiforme have been reported.20 Dinitrophenol, a metabolite of dinitrochlorobenzene, has been reported to cause hepatic and renal changes, convulsive seizures and hyperthermia.21

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