The 100% clinical clearance and 0% recurrence rate was offset by poor healing in 20% of lesions.43 Poor healing in this study was defined as a residual ulcer requiring salvage surgery, that ceased to show signs of continuing reduction in diameter, or considered by the dermatologist to be progressing poorly over at least 3 months Other reported adverse effects from uncontrolled studies included minor pain and burning during the procedure,51,52 short-term hypopigmentation,52 radiation dermatitis and radionecrosis.51 Poor healing, including radionecrosis, appear to be associated with older age, an irradiation field diameter >4 cm, and a total dose >3000 cGy.4351

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