Complications of methotrexate therapy include bone marrow suppression, nausea and vomiting, hepatotoxicity, and hypersensitivity pneumonitis.28 Albertini et al.48 described a patient with severe systemic and ulcerative sarcoidosis who was started on methotrexate, 25 mg per week. Although her ulcerative lesions initially regressed, she soon developed anaemia, leucopenia and elevated aspartate transaminase level, necessitating the withdrawal of methotrexate. The patient subsequently died of her disease. Major toxic effects noted by Lower et al. were hepatotoxicity, leucopenia and cough.42
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Do You Suffer From the Itching and Scaling of Psoriasis? Or the Chronic Agony of Psoriatic Arthritis? If so you are not ALONE! A whopping three percent of the world’s populations suffer from either condition! An incredible 56 million working hours are lost every year by psoriasis sufferers according to the National Psoriasis Foundation.