Hydroxyurea is a systemic therapy for severe psoriasis which is mainly used as a substitute for more commonly used systemic drugs such as ciclosporin or methotrexate when these are contraindicated. The evidence for its efficacy has been considered in a systematic review.59 Hydroxyurea has not been directly compared with other systemic therapies. Side-effects include bone-marrow suppression and teratogenicity. There is a need for high-quality RCTs of hydroxyurea both against placebo and against other systemic agents.
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Do You Suffer From the Itching and Scaling of Psoriasis? Or the Chronic Agony of Psoriatic Arthritis? If so you are not ALONE! A whopping three percent of the world’s populations suffer from either condition! An incredible 56 million working hours are lost every year by psoriasis sufferers according to the National Psoriasis Foundation.