We found no evidence. Key points

• We found one RCT which shows usefulness of aciclovir in preventing the recurrence of EM.

• We found little or controversial evidence on the effects on corticosteroids in the treatment of an acute attack of EM. Early administration reduces the duration of fever but may cause many side-effects.

• While levamisole showed some benefit, the benefit/risk ratio was considered too low.

• We found no good evidence on all other therapeutic choices (erythromycin, dapsone, antimalarials, azathioprine, ciclosporin, thalidomide, potassium iodide, cimetidine, immunoglobulins).

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