Implications for clinical practice

PUVA or UVB is effective. The choice for this treatment option is guided by considerations other than proven clinical superiority over other modalities.

In adults with chronic hand eczema, does treatment with PUVA irradiation (oral or topical psoralen) lead to better reduction in patient-and doctor-rated scores and remission periods than UVB irradiation?

We identified one RCT on oral PUVA and two CCT's on oral/topical PUVA. The controlled trial on topical bath PUVA demonstrated no comparative advantage, whereas the RCT on oral PUVA showed an effect in favour of PUVA.

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