Benzoyl peroxide is an effective treatment for mild-to-moderate acne vulgaris as a result of its activity against both IL and NIL. Some individuals find benzoyl peroxide to be highly irritant on initial application. Tolerance is generally developed with prolonged exposure and individuals should be counselled accordingly. Low-strength benzoyl peroxide is recommended as higher strengths are more irritant and there is no evidence to suggest that 10% in general is more effective than 5%. It is common practice for patients to apply benzoyl peroxide to individual lesions alone; clinicians should advise patients to apply it in a thin layer to all areas to prevent the formation of new lesions.
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