The comoedolytic action of topical retinoids suggests that they should be used in the treatment of mild acne. However, as this activity halts subsequent lesion formation, they are also suitable for moderate-to-severe acne and can be used in conjunction with topical and oral antibiotics. Benzoyl peroxide inactivates tretinoin, so the two agents should not be applied simultaneously; if used in combination, one should be applied in the morning and one at night. All topical retinoids cause local sensitivity reactions that appear to be less common with adapalene. To limit local sensitivity, topical retinoid therapy should start at a lower strength applied every third night and increase gradually.
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