Implications for practice

The comoedolytic action of topical retinoids suggests that they should be used in the treatment of mild acne. However, as this activity halts subsequent lesion formation, they are also suitable for moderate-to-severe acne and can be used in conjunction with topical and oral antibiotics. Benzoyl peroxide inactivates tretinoin, so the two agents should not be applied simultaneously; if used in combination, one should be applied in the morning and one at night. All topical retinoids cause local sensitivity reactions that appear to be less common with adapalene. To limit local sensitivity, topical retinoid therapy should start at a lower strength applied every third night and increase gradually.

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Acne Myths Uncovered

Acne Myths Uncovered

What is acne? Certainly, most of us know what it is, simply because we have had to experience it at one time or another in our lives. But, in case a definition is needed, here is a short one.

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