We found no systematic reviews. One randomised controlled trial (RCT) and one observational comparison study confirm that intradermal injections of triamcinolone acetonide, 5 mg/ml by a needle-less injector, produced rapid regrowth of hair in a high proportion of subjects with limited disease, within 4-6 weeks.
What are the effects of treatment for patchy alopecia areata?
In a report of 84 patients using normalsaline controls, 86% of patients treated with triamcinolone responded, compared with only 7% of control patients.12 Injections of triamcinolone acetonide, 0-1 ml of 5 mg/ml, were given at weekly or two-weekly intervals on three occasions. The number of injections was determined by the size of the area of alopecia, with each injection producing a tuft of hair approximately 0-5 cm2. Ninety-two per cent of patients with localised disease showed regrowth at 6 weeks, compared with 61% of those with alopecia totalis. This decreased to 71% at 12 weeks for alopecia areata and 28% for patients with alopecia totalis.
In an observational study comparing triamcinolone acetonide and triamcinolone hexacetonide involving 34 areas of alopecia in 11 patients, 64% of the sites injected with triamcinolone acetonide and 97% of the sites injected with triamcinolone hexacetonide regrew.13
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