Key points

• Oral antihistamines have been extensively 9 studied.

• Scholarly approaches to this treatment modality have resulted in few assertions.

• Antihistamines are not demographically effective and classical interpretations of 10 RCTs have discouraged their use.

• The individuality of effect of an antihistamine on any one person or given situation is variable enough to allow us to ignore pooled studies and to go on to recommend antihistamines in those contexts, or for those patients, where a potential benefit is obvious or already 12. noted by either the patient, physician or carer.

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