Key points

• Erythema multiforme, SJS and TEN are still used with different definitions. This does not allow correct literature analysis.

• We found insufficient evidence about effective treatments.

• We found only one placebo-controlled RCT, which showed a higher mortality with thalidomide.

• We found no good evidence on the effects of corticosteroids.

• We found no evidence of the value of tests.

• We found insufficient evidence of the effect of drug reintroduction.

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