Key points

• Few RCTs on systematic review of treatments for BP were identified.

• The available evidence is inadequate to allow confident recommendation of optimal treatment.

• A less aggressive approach to therapy with low doses of corticosteroids may be sufficient for disease control and appears to be associated with less morbidity and mortality.

• Tetracyclines and nicotinamide may be effective but larger trials are needed to compare this therapy with low-dose prednisolone.

• The benefits of azathioprine and plasma exchange are difficult to assess.

Additional chapters on Cicatrical pemphigoid and Epidermolysis bullosa acquisita by Maria Roest are published on the book website http://www. evidbasedderm.com.

Are antimicrobials useful?

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