Key points Prevention

• There is no evidence in the literature for a so-called Candida hypersensitivity syndrome.

• There is no RCT that supports eradication in colonised subjects who do not have an associated disease.

• In certain medical situations, such as in critically ill patients, those undergoing cancer chemotherapy, or those with complication of HIV infection, the majority of studies give evidence for a benefit of prophylactic antifungal therapy, especially in patients who are colonised with yeasts.

• There is limited evidence for any major differences between the possible treatment modalities (for example nystatin, ketoconazole, or fluconazole). In general, side-effects of this treatment are easily managed.

• There is no evidence that long-term treatment is of benefit.

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