Key points

• Lichen planus is a chronic inflammatory disease mainly affecting skin and oral mucosae. The objectives of the treatment vary according to the clinical forms. There is a lack of large trials comparing the usually recommended treatments with placebo.

• We found no evidence of efficacy of systemic or topical corticosteroids although this treatment is usually recommended as first-line treatment for cutaneous LP.

• We found limited evidence of acitretin efficacy and PUVA therapy efficacy in cutaneous LP.

• We found the benefit/harm ratio of ciclosporin in cutaneous LP to be too low to recommend this treatment.

• We found limited evidence of efficacy of topical corticosteroids, topical 0-1% tretinoin gel and 0-1% isotretinoin gel in oral LP.

• We found no evidence that topical ciclosporin is more effective than topical corticosteroid in oral LP.

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