Levamisole appeared useful in one RCT. Benefits

We found a double-blind placebo-controlled crossover trial, which included 14 patients with chronic or recurrent EM resistant to corticosteroid therapy. Levamisole was used at a dose of 150 mg/day for three consecutive days each week, for at least 4 weeks after first appearance of a lesion. Levamisole allowed decrease of severity, duration and frequency of EM attacks.12

An open comparative trial showed similar efficacy of levamisole used alone (17 patients; 76% complete response) versus a combination of prednisone and levamisole (22 patients; 82% complete response).13

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