Masoprocol (meso-nordihydroguariaretic acid) is a potent 5-lipoxygenase inhibitor with antitumour properties, investigated for use in AK.100

Quality of evidence: I

We found two double-blind RCTs.62 100 The first study101 compared masoprocol (n = 113) with topical placebo (n = 41), and the second study62 compared masoprocol (n = 27) with topical 5% 5-FU (n = 30). Both studies reported 1-month follow up following end of treatment.

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