Melagenine pseudocatalase systemic antioxidant therapy

One small trial on 20 patients found no clinical differences between melagenine- and placebo-treated groups.23 The effects of the other therapies, proposed on a theoretical basis, are unknown.24

What are the effects of surgical treatment?

In general, autologous transplantation methods are indicated for stable and/or focal lesions that are refractory to medical therapy.24 Koebner phenomenon should be absent, and tendency for scar or keloid formation should be ascertained. "Stable" disease is not uniformly defined across the studies.

Even after successful grafting, depigmentation of the grafts may still occur during "reactivation" of the disease.25

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