Methods of search

We searched Medline from 1966 to 2001. We first performed a highly sensitive search using the truncated term "Kaposi*", which generated over 8400 abstracts. We then performed a more specific Medline search using "sarcoma, Kaposi" [MeSH terms] or "Kaposi's sarcoma" [text word] combined with the following interventions AND [surgery, laser*, photodynamic therapy, cryotherapy, cryosurgery, intralesional therapy, intralesional vincristine or vinblastine, radiotherapy, interferon, chemotherapy, anthracycline, bleomycin, vinca-alkaloid, vincristine, vinblastine, taxane, paclitaxel, liposomal therapy, gemcitabine, navelbine, thalidomide, antiangiogenic agent, retinoids, retinoic acid, antiretroviral therapy, zidovudine, ganciclovir, cidofovir or foscarnet].

We also searched the Cochrane Central Register of Controlled Trials and Database of Systematic Reviews using the search terms "Kaposi" and "Kaposi's sarcoma".

QUESTIONS

What are the effects of local therapies in Kaposi's sarcoma (surgical excision, cryotherapy, photodynamic therapy and intralesional chemotherapy)?

We found no systematic reviews or randomised controlled trials of local therapies in KS. There were a relatively small number of uncontrolled phase II studies of each of the above interventions.

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