Newer cytotoxic drugs

There have been no phase III studies of newer agents such as vinorelbine and gemcitabine in KS. Vinorelbine has been used in an uncontrolled phase II study of 35 evaluable patients with AIDS-related KS who had progressed on one or more previous systemic chemotherapies. An overall response rate of 43% was found.67

One phase II study of gemcitabine in 11 evaluable patients with recurrent classical KS after previous chemotherapy reported 10/11 partial responses and one complete response.68 Gemcitabine was given at 1-2g/week for 2 weeks followed by a 1-week gap, and was continued until maximum response was achieved.68

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