• Did the study investigators use an adequate disease definition?
• Did they use outcome measures that mean something to you and your patient?
• Were the treatment groups similar with respect to predictors of treatment response at baseline?
• Were the main outcome measures declared a priori or did the investigators "data dredge" amongst many outcomes for a statistically significant result?
• Did the investigators do an appropriate statistical test if the data were skewed?
• Did the investigators test the right thing (i.e. between-group differences rather than just differences from baseline)?
• Have the authors misinterpreted no evidence of an effect as being evidence of no effect?
• Were the groups treated equally except for the interventions studied?
• Who sponsored the study? Could sponsorship have affected the results or the way they were reported?
• Is the trial clearly and completely reported by CONSORT standards?
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