One trial of the pulsed dye laser40 involving 40 patients showed no significant difference in cure rates between four pulsed dye laser treatments at monthly intervals and "conventional treatment" with either cryotherapy or cantharidin.
5-Fluorouracil and intralesional interferons as treatments for warts are more of historical interest. Four41-44 and six45-50 trials, respectively, were found for these treatments, most dating from the 1970s and 1980s. Evidence provided by all the trials was severely limited by heterogeneity of methodology and design and overall did not suggest any striking efficacy of either treatment.
No RCTs were identified that studied the efficacy of the following treatments: carbon dioxide laser, surgical excision, curettage and cautery, formaldehyde, podophyllin and podophyllotoxin.
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