Outcomes range from recovery to slowing of the disease progress. Mycetoma is rarely fatal and in even extensive disease the main problems are deformity and disability. In a few cases where the disease affects areas close to vital structures, such as the chest wall or cranium, the outcome is fatal.

The main approaches to management are therefore chemotherapy, combined in some cases of eumycetoma with surgery. Surgery itself may cause problems, particularly if this involves removing tissue from weight-bearing areas where the lack of support may result in pain and further disability.

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