The critical appraisal toolbox33

Editor: Michael Bigby

5. Formulating well-built clinical questions 35 Berthold Rzany and Michael Bigby

6. Finding the best evidence 38 Michael Bigby

7. The hierarchy of evidence 44 Michael Bigby

8. How to critically appraise systematic reviews and meta-analyses 49 Michael Bigby and Hywel Williams

9. How to critically appraise a study reporting effectiveness of an intervention 56 Hywel Williams

10. How to assess the evidence for the safety of medical interventions 64 Luigi Naldi

11. How to critically appraise pharmacoeconomic studies 70 Suephy C Chen

12. Applying the evidence back to the patient 76 Hywel Williams

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