PDT versus cryotherapy

In a trial of 88 patients, PDT was compared with two freeze-thaw cycle cryotherapy for BCC.31

Efficacy

There was no significant difference in recurrence rates at 12 months. Histological recurrence rates

Table 26.3 Randomised controlled trials evaluating photodynamic therapy in the treatment of basal cell carcinoma

Study

Method

Participants

Interventions

Outcomes

Notes

Wang et al.

Single centre

HP BCC

T1: PDT (20% weight-

FU: 1, 4, 8 weeks,

Ex: BCC on nose;

20013"

Randomised

44 women; 44 men;

based ALA/water-in-

3 months after

M growth;

(Sweden)

according to a

age range 42-88 years

oil cream applied to

treatment

porphyria;

stratified

Type: T1: 22 S, 25 N;

lesion; irradiation 6 hr

Last FU 12 months

abdominal pain

randomisation

T2: 17 S, 24 N

later.

after first treatment

of unknown

pattern in blocks

Distribution: 47 trunk,

T2: cryosurgery (2

Punch biopsy at

aetiology;

of 10 patients PP

25 head and neck,

freeze-thaw cycles)

3 and 12 months

photosensitivity;

10 legs, 6 arms

treatment of BCC

with topical

steroids type III

or IV within the

last month

Soler et al.

Single centre

HP BCC

All lesions in both

FU: 3, 6 months after

200032

Randomisation

83 patients

groups topical 20%

treatment

(Norway)

numbers in locked

245 lesions

ALA, removed after

Outcomes: complete,

envelopes. The

3 hours and light

partial or no response;

patients were

source applied: T1:

cosmetic outcome and

randomly allocated

laser light (630 nm);

pain intensity during

on the treatment

T2: broadband light

treatment and FU

day to one of the

two arms in blocks

of four patients ITT

See Table 26.1 for abbreviations.

See Table 26.1 for abbreviations.

at 1 year were 25%(11 of 44) in the PDT group, compared with 15% (6 of 39) in the cryotherapy group, despite multiple retreatments in the PDT group. Scarring and tissue defect scored significantly better following PDT.

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